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Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase

used in some protocols but less characterised

For young patients with mild disease not desiring children, it is advisable to use medical suppression to control symptoms and minimize surgical interventions

References Zhang X et al (2020) Pigment epithelium-derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2: a potential treatment strategy for missed abortion

Third, functional validationthrough microbial transplantation, targeted microbial modulation, and metabolite intervention experimentswill be critical to translate correlative findings into actionable mechanisms