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JAMA 309:23712381 Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R (2021) Small molecule SARM1 inhibitors recapitulate the SARM1(-/-) phenotype and allow recovery of a metastable pool of axons fated to degenerate
Hallmarks of trained immunity at the HSC level include increased HSC proliferation, expansion of myeloid-biased multipotent progenitor 3 (MPP3), and myeloid-biased differentiation 14,15
I mean, well, what would happen
Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements
See the evidence for tart cherry juice health benefits from clinical studies
