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GLP-1 Agonists: Treatment Failure Does Not Preclude Prevention The November 2025 announcement from Novo Nordisk that oral semaglutide failed to slow Alzheimers progression in the EVOKE and EVOKE+ trials was widely reported as a setback

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Notably, NS workers demonstrated stronger SARS-CoV-2-specific T-cell responses, and sleep metrics were not significantly associated with vaccine immunogenicity, suggesting that primary immune responses may be resilient to short-term sleep loss in healthy individuals 121

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