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Diet al.so significantly influences gut microbiota composition [25]

Immunity 40 , 608620 (2014)

Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

Science 371 , 265270 (2021)

Although primarily localized in the cytoplasm, RIG-I is also sequestered in the nucleus, mitochondria, microsomes, and mitochondria-associated membranes [223]