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Efficacy and safety of basimglurant as adjunctive therapy for major depression: a randomized clinical trial

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Additionally, arachidonic acid-15-lipoxygenase (ALOX15) knockdown or treatment with the lipoxygenase inhibitor baicalein has shown protective effects against ischemic brain damage in murine models ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA