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Acknowledgements The authors research is supported by US National Cancer Institute grants P01 CA-138338 (S.S.H.), R01 CA-081301 (S.S.H.) and P01 CA-217806 (D.K.H.) and by US National Institute on Drug Abuse grant U54 DA-031659 (D.K.H.)

However, roflumilast, a phosphodiesterase-4 inhibitor, appears to be more effective in patients with a neutrophilic phenotype, which may become a therapeutic agent for the neutrophil-mediated inflammatory response (101, 102)

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How does the capsule work? Squeeze the filter to release the flavour