The dynamin-related protein (Drp-1) and its mitochondrial adaptor fission protein 1 (Fis-1) are the main responsible for mitochondrial fission, a process positively related to mitochondrial fragmentation and apoptosis ( in vitro and in the rat hippocampus, leading to decreased elongated mitochondria, abnormal cristae depletion, apoptosis, and consequently loss of NSPCs proliferation/differentiation balance
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This is shorter than standalone GHK-Cu cycles because BPC-157 and TB-500 receptors desensitize faster than GHK-Cu's gene modulation pathway
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