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Vande Casteele T, Laroy M, Van Cauwenberge M, Koole M, Dupont P, Sunaert S, et al

10.1136/bmj.315.7109.629 21 FieldE

Withdrawal from social activities: Losing interest in work, hobbies, or socializing, and avoiding previously enjoyable activities

rosea demonstrates neurotrophic capabilities by enhancing the expression of BDNF and facilitating the activation of downstream TrkBCREB signaling pathways, which are essential for synaptic plasticity, neuronal survival, and neurogenesis (56)