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High Blood Pressure : People who have diabetes and smoke have a much higher risk of blood vessel damage from inflammation

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Michael easily overpowers him, because it is Only Boone, but then Locke pushes back on Michaels objections, telling Michael that Walt is special and should be allowed to realize his potential, so double yikes

This low lethal dose makes nicotine more toxic than many other compounds including even alkaloids such as cocaine which has a median lethal dose of 95.1 mg per kg in mice