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To maximize the benefit, radiotherapy is often supplemented with either radiosensitizers to intensify the radiation-induced cytotoxicity through augmenting biomolecular damage (e.g., DNA damaging agents) or radioprotectors to mitigate the deleterious effect of ionizing radiation in normal tissues mostly by scavenging highly reactive free radicals (e.g., antioxidants)

MDA, LPCAT3, and prostaglandin-endoperoxide synthase 2 (PTGS2) expression were significantly increased, promoting neuronal ferroptosis and lipid peroxidation in EAE mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Lantier L., Mounier R., Leclerc J., Pende M., Foretz M., Viollet B

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