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Taken together, the findings in this study point to the use of P-gp-induced ROS as a mechanism to limit the rise of drug efflux dependent resistant tumor cells pre- or post-treatment with chemotherapeutic drugs

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doi: 10.1016/j.arcmed.2016.07.003 225 Samsami-korMDaryaniNEAslPRHekmatdoostA

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Neuroscience 316 , 209220 (2016)

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Uric acid prevents lysis of erythrocytes by peroxidation and is a potent scavenger of singlet oxygen and hydroxyl radicals

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To further verify the mechanism of NSBSO-induced cell death in 4T1 cells, lipid peroxidation and micromorphology of mitochondria were examined

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