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Supplementation with gamma-glutamylcysteine (gamma-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD

Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)

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doi: 10.1101/2024.09.19.613992 60

ROXY9 is oxidized to ROXY9-S 2 depending on the redox potential of the GSH/GSSG couple, while class I GRXs adopt a stable equilibrium between the glutathionylated and the S 2 -containing state over a wide range of redox potentials established by GSH/GSSG