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It has been observed to upregulate genes associated with tissue repair and antioxidant defense while downregulating genes linked to inflammation and fibrosis
The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)
While the precise role of ROS in the pathophysiology of AD has yet to be fully understood, numerous studies have shown that dietary factors which behave as antioxidants, modulate oxidative stress and gene expression of antioxidant enzymes
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