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Clinical Evidence Gaps and What Remains Unanswered Despite decades of research interest, GHK-Cu lacks large, multi-center, placebo-controlled human trials

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Targeting the IGF-1R signaling pathway is considered a potential breakthrough in anticancer therapy and a number of small molecule inhibitors and monoclonal antibodies targeting IGF-1R, such as BIIB-022, BMS-754807 and Teprotumumab, have been developed and evaluated in clinical trials (113115)

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