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Cigarettes yield the highest blood nicotine level that can be achieved - just 3 puffs results in 85% of those nicotinic acetylcholine receptors being occupied by nicotine, a whole cigarette results in 99% occupation

Despite these limitations, the direction of the evidence has not substantially changed in recent years, but rather has been reinforced

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However, the longevity and efficiency of dokha tobacco offer substantial savings over time